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目的根据抗菌药物的药动学/药效学(PK/PD)理论,应用蒙特卡罗模拟评价氟喹诺酮类药物在治疗尿路大肠埃希菌感染时,不同给药方案的疗效。方法对莫西沙星、左氧氟沙星和环丙沙星静脉给药方案治疗尿路大肠埃希菌(Escherichia coli)的效果进行蒙特卡罗模拟,将获得的累积反应分数(CFR)作给药方案的比较。结果静脉给予左氧氟沙星0.50 g qd、0.75 g qd的给药方案治疗尿路大肠埃希菌的CFR>90%,为有效的治疗方案;而莫西沙星0.40 g qd以及环丙沙星0.20 g q12 h、0.50 g q12 h的给药方案CFR<90%,不作为推荐给药方案。结论对于尿路大肠埃希菌感染,左氧氟沙星0.50 g qd、0.75 g qd为氟喹诺酮类药物的有效给药方案;莫西沙星、环丙沙星对尿路大肠埃希菌的效果不理想。
OBJECTIVE According to the pharmacokinetics / pharmacodynamics (PK / PD) theory of antimicrobial agents, Monte Carlo simulation was used to evaluate the efficacy of fluoroquinolones in the treatment of E.coli urinary tract infections. Methods The effects of moxifloxacin, levofloxacin and ciprofloxacin intravenous administration on Escherichia coli in urinary tract were simulated by Monte Carlo method, and the cumulative response fraction (CFR) obtained was compared with the dosage regimen . The results of intravenous levofloxacin 0.50 g qd, 0.75 g qd dosing regimen for the treatment of urinary Escherichia coli CFR> 90%, as a valid treatment; and moxifloxacin 0.40 g qd and ciprofloxacin 0.20 g q12 h , 0.50 g q12h dosing regimen CFR <90%, not as the recommended dosing regimen. Conclusion For urinary Escherichia coli infection, levofloxacin 0.50 g qd, 0.75 g qd for the fluoroquinolones effective dosing regimen; moxifloxacin, ciprofloxacin on urinary tract E. coli is not ideal.