虽然枸橼酸克罗米芬(Clomiphene)对男女性下视丘—垂体轴的作用方式似乎相似,然而在治疗男性精子生成功能低下上却不能与广泛用于治疗女性排卵衰竭一样。其部分原因可能是由于早期临床研究认为高剂量的克罗米芬能引起精子数量降低,在睾丸活检时则发现异形增多和令人惊异的变化。用在男性中以短疗程为基础的克罗米芬是一种强力的科研的药剂,几年来已有过报告,但有关于长疗程的应用问题,直至Paulson和Wacksman用显著低于女性用的小剂量的克罗米芬的一些成功的报告之后才听 Although Clomiphene citrate acts similarly to the hypothalamus-pituitary axis in both men and women, it is not as effective in treating men with poor sperm production as is widely used to treat female ovulation failure. This may be due in part to early clinical studies suggesting that high doses of clomiphene may cause a decrease in the number of sperm and that there is anomalous and surprising changes on the testicular biopsy. Clomiphene, which is based on a short course of treatment in men, is a potent scientific agent that has been reported for several years but has long been in use for a long course of treatment until Paulson and Wacksman used a significantly lower dose than women After some successful reports of clomiphene