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目的 :探讨红霉素治疗妊娠期宫颈沙眼衣原体 (CT)感染的有效性和安全性。方法 :将 2 3 6例患者分为治疗组和对照组。治疗组口服红霉素 ( 0 .2 5g ,q6h) ,14d为 1个疗程 ,对照组口服安慰剂 (维生素C片 ) 0 .1g ,q6h。结果 :治疗组治疗 1个疗程CT转阴率 68.6% ,2个疗程CT转阴率 10 0 % ;随访 82例 ,均足月分娩 ,母婴正常。对照组 :96例中 5例自然流产 ,4例胎膜早破 ,3例早产 ,2例新生儿CT感染 ,4例宫颈CT自然转阴。结论 :CT感染影响妊娠结局。红霉素治疗妊娠合并CT感染安全有效 ,对胎儿无毒副作用
Objective: To investigate the efficacy and safety of erythromycin in the treatment of gestational cervical Chlamydia trachomatis (CT) infection during pregnancy. Methods: 236 cases were divided into treatment group and control group. The treatment group oral erythromycin (0. 25g, q6h), 14d for a course of treatment, the control group oral placebo (vitamin C tablets) 0 1g, q6h. Results: In the treatment group, the CT negative rate was 68.6% in one course of treatment and the CT negative rate in two courses was 100%. All the patients were followed up for 82 months. Control group: 5 cases of spontaneous abortion in 5 cases, 4 cases of premature rupture of membranes, 3 cases of premature birth, 2 cases of neonatal CT infection, 4 cases of cervical CT naturally negative. Conclusion: CT infection affects pregnancy outcome. Erythromycin treatment of pregnancy complicated with CT infection safe and effective, non-toxic side effects on the fetus