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目的:探讨枸橼酸莫沙必利分散片对老年功能性消化不良(FD)患者胃功能的影响。方法:将2012年3月~2014年3月我院79例老年FD患者(FD组)给予口服枸缘酸莫沙必利分散片,并随机抽取同一时期120例我院健康体检者为对照组,检测并比较两组的胃底气体的评分、延迟排空相、近端胃容积以及近端胃液体半排空时间。结果:FD组治疗前延迟排空相大于对照组,近端胃液体半排空时间小于对照组,差异有统计学意义(P<0.05),两组的胃底气体的评分差异无统计学意义(P>0.05);FD组治疗后延迟排空相小于治疗前,近端胃液体半排空时间大于治疗前,差异有统计学意义(P<0.05);FD组治疗前0 min、5 min、15 min、30min、60 min的近端胃容积均小于对照组,差异均有统计学意义(P<0.05);FD组治疗后各时刻近端胃容积大于治疗前,差异均有统计学意义(P<0.05)。结论:老年FD患者采用枸缘酸莫沙必利分散片治疗可明显改善患者的胃功能,促进胃排空的速度,值得临床推广。
Objective: To investigate the effect of mosapride citrate dispersible tablets on gastric function in elderly patients with functional dyspepsia (FD). Methods: From March 2012 to March 2014, 79 elderly FD patients (FD group) in our hospital were given oral Mosapride clopidogrel tablets and 120 healthy people in our hospital were randomly selected as the control group , The scores of gastric gas in the two groups were detected and compared, the emptying phase, the proximal gastric volume and the half gastric emptying time of the proximal gastric juice were delayed. Results: The delayed evacuation phase of FD group before treatment was longer than that of control group, and the half-emptying time of proximal gastric juice was less than that of control group (P <0.05). There was no significant difference between the two groups (P> 0.05). The delayed evacuation phase of FD group was less than that of before treatment, and the time of half emptying of proximal gastric fluid was longer than that before treatment (P <0.05) , The proximal gastric volume at 15 min, 30 min and 60 min were all significantly lower than those in the control group (P <0.05), and the difference of the proximal stomach volume at each time point after treatment was statistically significant (P <0.05). Conclusion: The elderly FD patients treated with mosapride citrate tablets can significantly improve the patient’s gastric function and promote gastric emptying speed, worthy of clinical promotion.