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15只家兔分三组,分别静注30mg/kg,吸入暴露126和391ppm 氯仿中。用液上GC/MS 多离子检测技术定时测量观察血液氯仿浓度(C_b)的时间过程。在暴露6h 期间内,C_b 迅速上升,并基本维持在坪浓度2.37或25.0μg/ml 处,在暴露终止后,呈双相半对数-线性衰减,与二室线性药代动力学模型计算的浓度-时间曲线吻合。同时获得 t_((1/2)α)和 t_((1/2)β)分别为0.15～0.53h和1.3～1.6h,F 为15.5～52.5%等毒物动力学参数。
15 rabbits were divided into three groups, intravenous injection of 30mg / kg, inhalation exposure 126 and 391ppm chloroform. Time course of blood chloroform concentration (C_b) measurement was measured regularly using liquid GC / MS multi-ion detection technique. During the 6h exposure, C_b increased rapidly and remained at the plateau concentration of 2.37 or 25.0 μg / ml. After the termination of exposure, C_b was linearly decayed half-logarithmically and linearly with the two-compartment linear pharmacokinetic model Concentration - time curve match. At the same time, the kinetic parameters such as t_ ((1/2) α) and t_ ((1/2) β) were 0.15 ~ 0.53h and 1.3 ~ 1.6h respectively, and F was 15.5 ~ 52.5%.