糖尿病发病率逐年增高,与组织相容抗原DR_3、DR_4关系密切,病毒感染作为人类糖尿病的直接病因尚属罕见。在大鼠糖尿病模型中,T细胞减少早于或伴随胰岛素依赖型糖尿病(IDDM)的发病,虽可检出胰岛细胞抗体,但细胞介导免疫似系原发机制,环孢菌素(cy)可防止急性胰岛炎。在人类中,根据胰岛组织学,针对胰岛细胞的细胞介导免疫和胰岛细胞抗体的检出等证据,说明IDDM可能是一种自身免疫性疾病。从而也开创了免疫抑制 The incidence of diabetes increased year by year, and tissue-compatible antigens DR_3, DR_4 closely related to the virus infection as a direct cause of human diabetes is still rare. In rat model of diabetes mellitus, T cell depletion is earlier than or accompanied by the onset of insulin-dependent diabetes mellitus (IDDM), although islet cell antibodies can be detected, but cell-mediated immunosuppressive mechanisms, cyclosporine (cy) Acute insulitis can be prevented. In humans, IDDM may be an autoimmune disease based on evidence of pancreatic islet histology, cell-mediated immunity against islet cells, and detection of islet cell antibodies. Thus also created immune suppression