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目的探讨血小板输注疗效评估的相关实验室指标、血小板有效输注及无效输注后血小板相关参数[血小板计数(PLT)、血小板计算增高指数(CCI)、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)]的变化及临床意义,为血小板输注的疗效评价提供更多客观的实验室指标。方法 186例血小板输注患者为研究对象,检测输注前和输注后的PLT、CCI、MPV、PDW、PCT,观察输注前后的变化情况。结果 110例患者输注血小板有效,输注后CCI为9333,PLT、MPV、PDW、PCT均值均较输注前升高。76例患者输注血小板无效,输注后CCI<4500,PLT、MPV、PDW、PCT均值均较输注前降低。结论血小板输注有效时,血小板相关参数比输注前增高。血小板输注无效时,血小板相关参数比输注前降低。此结果可为血小板输注后疗效评价提供新的实验室客观依据。
Objective To investigate the correlation between platelet transfusion and platelet parameters (platelet count (PLT), platelet count index (CCI), mean platelet volume (MPV), platelet distribution width (PDW) and platelet pressure (PCT)], and provide more objective laboratory indexes for evaluating the efficacy of platelet transfusion. Methods A total of 186 patients with platelet transfusion were enrolled in this study. PLT, CCI, MPV, PDW and PCT were measured before and after transfusion. The changes before and after transfusion were observed. Results 110 patients were transfused with platelets, CCI was 9333 after infusion, PLT, MPV, PDW, PCT mean increased than before infusion. Sixty-six patients were ineffective in transfusion of platelets. After CCI <4500, the mean PLT, MPV, PDW and PCT were all lower than those before infusion. Conclusion When platelet transfusion is effective, the relevant parameters of platelets are higher than those before transfusion. When platelet transfusions were ineffective, platelet-related parameters were lower than before transfusion. This result can provide a new laboratory objective basis for evaluating the efficacy of platelet transfusion.