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对吗啡受体拮抗剂纳曲酮生物降解分散系的深入研究表明 ,纳曲酮的长效缓释制剂可克服病人在长达数月乃至数年的阿片成瘾治疗过程中产生的不适应。纳曲酮的结构与吗啡极为相似 [1] ,目前初步研究所得剂型为固形植入剂 ,需手术皮下埋植。因而 ,需探索可注射用的植入剂 :小颗粒混
In-depth studies of the morphine receptor antagonist naltrexone biodegradable dispersion show that long-acting sustained-release formulations of naltrexone can overcome the patient’s incompatibility with opiate addiction over months and even years. The structure of naltrexone and morphine are very similar [1], the initial study of the resulting dosage form of solid implant, surgical implants need surgery. Therefore, the need to explore injectable implants: small particles mixed