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本文探讨了加温合并喜树碱、斑蝥素对荷Ｌｅｗｉｓ肺癌ＮＩＨ小鼠的抗肿瘤作用以及热耐受性对其作用的影响。结果：①喜树碱１６ｍｇ／ｋｇ或斑蝥素０．４５ｍｇ／ｋｇ合并２５ｍｉｎ加温能抑制肿瘤生长，在４１～４３℃范围内随温度的升高而加强；②在加温４３℃，２５ｍｉｎ时，加温合并喜树碱１２ｍｇ／ｋｇ或斑蝥素０．４５ｍｇ／ｋｇ产生相加作用；③热耐受性在４３℃，２５ｍｉｎ加温后迅速产生，２４ｈ达高峰而后递减；热耐受性极大地影响了喜树碱和斑蝥素的抗癌效果。
This article explores the effects of warming combined with camptothecin and cantharidin on the antitumor activity of NIH mice bearing Lewis lung carcinoma and the effects of thermo tolerance on it. Results: ① Camptothecin 16mg / kg or cantharidin 0.45mg / kg combined with 25min heating can inhibit tumor growth, in the range of 41 ~ 43 ℃ with the increase of temperature; ② heating at 43 ℃, 25min , Warming with camptothecin 12mg / kg or cantharidin 0.45mg / kg add; ③ heat tolerance at 43 ℃, 25min after warming quickly produced, reached a peak at 24 hours and then decreased; heat tolerance pole The earth affected the anti-cancer effect of camptothecin and cantharidin.