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目的研究肝炎患者肝组织中丙型肝炎病毒抗原的表达及其临床意义。方法以抗－ＨＣＶＮＳ４ＭｃＡｂ对７７例肝炎患者肝穿标本进行检测。结果ＨＣＶ－Ａｇ（ＮＳ４）呈细小颗粒状位于肝细胞浆中。急慢性肝炎肝组织ＨＣＶ－Ａｇ阳性肝细胞呈散在分布；慢性重型肝炎肝内ＨＣＶ－Ａｇ阳性肝细胞呈弥漫分布。１５例血清抗－ＨＣＶ（＋）和ＨＣＶＲＮＡ（＋）患者中有１２例肝ＨＣＶ－Ａｇ（＋）；１１例血清抗－ＨＣＶ（＋）而ＨＣＶＲＮＡ（－）患者中有３例肝ＨＣＶ－Ａｇ（＋）。结论肝ＨＣＶ－Ａｇ表达与血清ＨＣＶＲＮＡ关系较为密切，ＨＣＶ－Ａｇ表达与ＨＣＶ致病机制有关。
Objective To study the expression of hepatitis C virus antigen in liver tissue of patients with hepatitis and its clinical significance. Methods Anti-HCV NS4 McAb was used to detect hepatic peritonitis in 77 hepatitis patients. Results HCV-Ag (NS4) was located in hepatocyte cytoplasm in the form of fine granules. HCV-Ag positive hepatocytes in acute and chronic hepatitis liver tissue were scattered; the intrahepatic HCV-Ag positive hepatocytes in chronic severe hepatitis were diffusely distributed. Among 15 patients with serum anti-HCV (+) and HCVRNA (+), 12 had HCV-Ag (+); 3 of 11 patients with anti-HCV (+ (+). Conclusion The expression of HCV-Ag in liver is closely related to the serum HCVRNA. The expression of HCV-Ag is related to the pathogenesis of HCV.