随着乙胺丁醇(EMB)的广泛临床应用,其副反应亦引起人们的日益重视,国内外文献报告不乏其例。但小剂量(0.5g)即致副反应者临床实属少见,尤其是儿童。作者最近遇1例,现报告如下: 病人赵某女 9岁门诊号865329。因咳嗽、低热、盗汗、消瘦、肺门淋巴结肿大,诊断为原发型肺结核,于1986年5月开始单用INH每日0.2g门诊督导化疗。3月后症状缓解,但肺门阴影未见明显吸收,于是加EMB每日0.25g。患儿于第2次服EMB后1小时,感双下肢发痒,继之双上肢、躯干亦搔痒,全身多处出现米粒及黄豆大淡红色丘疹及风团,6小时后部分风团自行消退,但感眼部不适,视物渐模糊,辨色力减弱。次晨患儿未再用药,除全身仍有痒感外,皮疹消失殆尽,但眼部症状未见减轻。查巩膜无黄染,结膜轻度充血,左眼视力0.7,右眼0.5(原均为1.5),眼底视乳头轻度水肿,视盘尚清晰。诊断为EMB副反应:过敏 With the extensive clinical application of ethambutol (EMB), its side effects have also drawn increasing attention. There are many reports in the literature both at home and abroad. However, small doses (0.5g) that cause side effects of clinical reactions are rare, especially children. The author recently encountered in 1 case, the report is as follows: Patient Zhao 9-year-old clinic No. 865,329. Due to cough, fever, night sweats, weight loss, hilar lymph nodes, diagnosis of primary pulmonary tuberculosis, in May 1986 began using INH daily 0.2g outpatient supervised chemotherapy. Symptoms after 3 months to ease, but hilar shadow no significant absorption, so plus EMB daily 0.25g. Children in the 2nd EMB after 1 hour, feeling the lower limb itch, followed by the upper extremities, torso also itch, the body appeared in many parts of rice and soy beans big pink papules and wind group, 6 hours after the wind group to subside , But the sensation of eye discomfort, depending on the material gradually blurred, reduced color force. The next morning, children no longer medication, in addition to the body still itching, the rash disappeared, but no reduction in ocular symptoms. Check sclera no yellow dye, conjunctival mild congestion, visual acuity of 0.7 left eye, right eye 0.5 (formerly 1.5), mild ocular fundus edema, optic disc is still clear. Diagnosed as EMB side effects: allergy