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目的观察氟比洛芬酯预处理对大鼠急性痛抗伤害效应,探讨氟比洛芬酯超前镇痛效应。方法大鼠按Brennan法制成切口疼痛模型,分为氟比洛芬酯组(P组)、对照组(C组),P组于造模前15min经尾静脉给药,C组于造模后即刻经尾静脉给药。2组分别再分为4组(各8只):即生理盐水组、氟比洛芬酯1,3,9mg/kg组;分别于术后2,24,48h进行累积疼痛评分和热板实验,观察注药后反应。结果在动物模型建立前或后给药,氟比洛芬酯均能产生量效相关的抗伤害效应,ED50分别为3.85,4.20mg/kg;95%的置信区间为(3.42,4.28)与(3.96,4.44)。P组3,9mg/kg的抗伤害效应评分及热痛阈在建立模型后2,24,48h时低于C组(P<0.05)。结论氟比洛芬酯能产生量效相关抗伤害效应,具有超前镇痛作用。
Objective To observe the anti-nociceptive effects of flurbiprofen axetil preconditioning on rats and to investigate the preemptive analgesic effect of flurbiprofen axetil. Methods The rats were made into incision pain model by Brennan method. The rats were divided into flurbiprofen ester group (group P) and control group (group C). Rats in group P were given via caudal vein 15 minutes before modeling and group C Immediate intravenous administration. Two groups were divided into 4 groups (8 rats each): normal saline group, flurbiprofen 1, 3, 9 mg / kg group; cumulative pain score and hot plate test , Observe the reaction after injection. Results Both flurbiprofen esters produced dose-effect-related antinociceptive effects before and after the establishment of animal models with ED50 of 3.85 and 4.20 mg / kg, 95% confidence interval (3.42 and 4.28) and ( 3.96, 4.44). At 3, 9 mg / kg in group P, the anti-injury effect score and the heat pain threshold were lower than those in group C at 2, 24, 48 h after model establishment (P <0.05). Conclusion Flurbiprofen can produce dose-effect-related antinociceptive effect and lead analgesia.