Modified magnetic nanoparticles have gained considerable attention because of their great potential applications in biomedical fields, such as protein and enzyme immobilization, bioseparation, immunoassays and biosensor etc. In recent years, great efforts have been made in developing targeted drug carriers by use of magnetic nauogels.Magnetic nanogels of common interest are ferromagnetic magnetite (Fe3O4) coated with cross-linked polymer nanogels. Several methods have been developed to prepare magnetic micro- and nanogels, such as inverse microemulsion polymerization, emulsion polymerization and other methods. In this paper, we propose an alternative approach to synthesize poly (N-isopropylacrylamide) (PNIPAM), polyacrylamide (PAM) superparamagnetic nauogels via photochemical reactions at room temperatures in au emulsion- and initiator-free aqueous system.Temperature-dependent magnetic nanogels weresynthesized by using NIPAM as monomer[1]. The PNIPAM-modified magnetic nauogels have the character of lower critical solution temperature (LCST),and its particle size is sensitive to environmental temperature. Polydispersity index of the magnetic nauogels modified with PNPAM are lower than 0.25(Fig. 1). The magnetic nauogels modified with PAM were prepared by using acrylamide (AM) as monomer.After Hoffinann elimination, nanogels with amino groups were also obtained[2]. Particle size of all the nauogels can be controlled by controlling the reaction time, the monomer concentration and the cross-linker concentration.High zeta potential of the magnetic nauogels were measured by PCS, and their core-shell structure and regular morphology were confirmed by TEM, AFM and SEM, respectively. The nauogels with amino groups were covalently radiolabeled with 188Re complex in vitro.In conclusion, a new approach to produce magnetic nanogels via photochemical reaction has been developed.Narrow size distribution magnetic nanogels with temperature-sensitive shell and amino groups have been synthesized successfully. This suggests promising potential applications for targeted drug carriers.