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鼻咽癌的治疗方法是以放疗为主的综合治疗,化疗是治疗中晚期鼻咽癌的重要手段。肿瘤细胞对多种化疗药物产生耐药是造成化疗失败的主要原因。研究鼻咽癌的多药耐药及其临床逆转已成为亟待解决的问题。对鼻咽癌进行多药耐药研究,预测化疗的敏感性,进行个体化的治疗,对提高鼻咽癌的化疗效果。有重要意义。建立鼻咽癌耐药细胞系,筛查耐药相关基因,探讨耐药基因的作用机理,寻找逆转药物耐受的分子靶点具有重要的理论和实际意义。
Nasopharyngeal cancer treatment is based on the comprehensive treatment of radiotherapy, chemotherapy is an important means of treatment of advanced nasopharyngeal carcinoma. Tumor cells are resistant to a variety of chemotherapeutic drugs is the main reason for the failure of chemotherapy. Research on multidrug resistance of nasopharyngeal carcinoma and its clinical reversal has become an urgent problem to be solved. Multidrug resistance of nasopharyngeal carcinoma research, predict the sensitivity of chemotherapy, individualized treatment, to improve the chemotherapy effect of nasopharyngeal carcinoma. There’s important meaning. It is of great theoretical and practical significance to establish a drug-resistant nasopharyngeal carcinoma cell line, screen drug-resistance-related genes, explore the mechanism of drug resistance genes and find molecular targets to reverse drug resistance.