红细胞刚性是指红细胞受外力作用时抗变形的能力,红细胞刚性增加是临床上常见的流变学现象。为研究这一现象的病理生理意义必须建立红细胞刚化模型。传统加热法使红细胞膜蛋白凝固而达到刚化目的,但同时破坏了红细胞表面带电特征,与临床情况差距很大。我们改进了传统加热法,并对其流变学性质进行了分析。 Erythrocyte rigidity refers to the ability of anti-deformation of red blood cells by external forces, increased rigidity of red blood cells is a common clinical rheology. In order to study the pathophysiological significance of this phenomenon, a model of erythrocyte rigidity must be established. The traditional heating method makes the erythrocyte membrane protein coagulate to achieve the purpose of rigidification, but at the same time undermines the charged characteristics of the erythrocyte surface, which is far from the clinical situation. We improved the traditional heating method and analyzed its rheological properties.