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自Combes等(1971)证明1例乙型肝炎的肾小球肾炎与HBsAg的关系以来,已有几例病人的肾脏应用免疫荧光方法确定有HBsAg存在。作者于1973～1978年,对163名患蛋白尿和/或血尿的日本儿童(男90例,女73例,年龄3～15岁),进行肾活检,发现膜性肾病11例(男9例,女2例),应用反相被动血凝检查血清HBsAg均为阳性;随访6个月～5年均未见阴转。其余152例为其它肾脏疾病,血清HBsAg阳性者仅7例(4.6%)。9例膜性肾病患者肾组织标本进行免疫荧光检查,大多数病例的肾小球上沿毛细血管袢有IgG沉积,而β_1C、IgA和IgM和纤维蛋白原沉积并非都有,如有,其分布与IgG相同,均未发现HBsAg的沉积。8例HBeAg检查6例阳性,抗HBe均为阴性。11例患者的母亲血清检查,6例HBsAG阳性,另1例含有抗HBs。母子
Since Combes et al. (1971) demonstrated that one patient with hepatitis B has a relationship with HBsAg, several cases of kidney disease have been identified by immunofluorescence in the presence of HBsAg. From 1973 to 1978, 163 Japanese children (90 males and 73 females, aged 3-15 years) with proteinuria and / or hematuria were examined by a renal biopsy and found that there were 11 cases of membranous nephropathy (9 males , 2 females), positive HBsAg was detected by reverse-phase passive hemagglutination. No follow-up was found after 6 months to 5 years of follow-up. The remaining 152 were other kidney diseases, with only 7 (4.6%) HBsAg positive. Nine patients with membranous nephropathy renal tissue samples for immunofluorescence, in most cases of glomerular capillary capillaries with IgG deposition, and β1C, IgA and IgM and fibrinogen deposition are not all, if any, the distribution As with IgG, no deposition of HBsAg was found. 6 cases of HBeAg positive in 8 cases, anti-HBe were negative. Eleven patients had their mother’s serum examined, 6 had HBsAG positive and the other had anti-HBs. Mother and child