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目的探讨参芪扶正注射液配合化疗治疗肺癌的增效减毒,改善肺癌化疗副反应的作用。方法将100例肺癌患者随机分为治疗组和对照组。治疗组化疗前3天用参芪扶正注射液250ml静脉滴入,每天1次,10天为一个周期。对照组为单纯化疗。结果治疗组总有效率为52%,对照组总有效率为32%,血液毒性白细胞降低Ⅱ度以上发生率治疗组为40%,对照组为62%,血小板分别为22%及44%,两组间有显著性差异(P<0.05)。同时体重及生活质量治疗组均较对照组提高,差异有显著性(P<0.05)。胃肠道反应治疗组较对照组明显减轻。结论参芪扶正注射液联合化疗有明显协同作用,能减轻化疗的副反应,保护造血系统,改善恶心、呕吐反应,使体重增加,提高患者的生活质量。
Objective To investigate the effect of Shenqi Fuzheng Injection combined with chemotherapy in the treatment of lung cancer with synergism and attenuation, and to improve the side effects of chemotherapy in lung cancer. Methods 100 patients with lung cancer were randomly divided into treatment group and control group. The treatment group was intravenously infused with 250 ml of Shenqi Fuzheng Injection 3 days before chemotherapy, once a day and 10 days as a cycle. The control group was chemotherapy alone. Results The total effective rate in the treatment group was 52%, and the total effective rate in the control group was 32%. The incidence of hematologic leukocytes lower than II degree was 40% in the treatment group, 62% in the control group, and 22% and 44% in the platelets, respectively. There was a significant difference between the groups (P<0.05). At the same time, the weight and quality of life in the treatment group were significantly higher than those in the control group (P<0.05). Gastrointestinal reaction group was significantly less than the control group. Conclusion Shenqi Fuzheng Injection combined with chemotherapy has a significant synergistic effect, can reduce the side effects of chemotherapy, protect the hematopoietic system, improve nausea, vomiting, weight gain, and improve the patient’s quality of life.