胶质细胞源性神经营养因子是近年来发现的一种蛋白质,特异性保护多巴胺能神经元,增加乙酰胆碱转移酶的活性,促进损伤后感觉及运动神经元的再生,对抗谷氨酸所致的神经元变性。在脑缺血性疾病中治疗效果持不同见解。近年研究显示外源性GDNF对多种神经疾病有神经保护作用,现就这一方面的研究做一综述。 Glial cell line-derived neurotrophic factor is a protein found in recent years that specifically protects dopaminergic neurons, increases the activity of acetylcholine transferase, promotes the sensory and motor neuron regeneration after injury, antagonizes glutamate-induced Neuronal degeneration. In the treatment of cerebral ischemic disease with different views. In recent years, studies have shown that exogenous GDNF neuroprotective effect on a variety of neurological diseases, is to do a review of this aspect of the study.