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干扰素(IFNs)和白间素(ILs)是两类不同细胞产生和不同刺激剂诱导的天然产生的蛋白质。IFNs有很强的抗病毒和抗细胞增殖性质,也有免疫调节作用。它们在人体内浓度极低。当大剂量给予时,使人体产生范围很广的不良反应。临床肿瘤治疗经验表明,IFNs和IL-2的副作用(除IL-2有液体滞留作用外)彼此相似。一、干扰素对人体的毒性 IFNs的功能与蛋白质和糖蛋白有关。根据糖蛋白的生理化学和生物学性质可分为三类:IFN-α和IFN-β由刺激的白细胞和成纤维母细胞产生,IFN-γ又称为免疫干扰素,由T淋巴细胞对抗原或促细胞分裂剂的
Interferons (IFNs) and interleukins (ILs) are naturally occurring proteins that are induced by two different cell types and by different stimulators. IFNs have a strong antiviral and anti-cell proliferative properties, but also immunomodulatory effects. They are extremely low in the human body. When large doses, the body produces a wide range of adverse reactions. Experience with clinical oncology has shown that the side effects of IFNs and IL-2, with the exception of IL-2, are similar to each other. First, the toxicity of interferon on the human IFNs function and protein and glycoprotein. According to the physiochemical and biological properties of glycoproteins can be divided into three categories: IFN-α and IFN-β by stimulated leukocytes and fibroblasts, IFN-γ, also known as immune interferon by T lymphocytes against the antigen Or mitogen