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目的:优化老鹳草的提取工艺,研究老鹳草凝胶剂的基质处方及制备工艺。方法:采用L9(34)正交试验方法,以干膏得率和没食子酸含量为指标,优化提取工艺;以制剂外观稳定性为指标进行基质筛选,以外观的综合评分为指标进行处方因素的筛查。结果:老鹳草凝胶剂的最佳提取工艺为加10倍量水,煎煮2次,每次1 h;最佳基质处方为卡波姆940 1.5%、甘油2%、丙二醇2%、三乙醇胺5%。结论:提取工艺简单可行,制备工艺稳定,成品易于涂布,质地均匀细腻。
Objective: To optimize the extraction process of geranium and to study the matrix prescription and preparation process of geranium gel. Methods: L9 (34) orthogonal test was used to optimize the extraction process based on the dry extract yield and gallic acid content. The stability of the preparation was used as matrix to screen the matrix. Screening. Results: The best extraction process of geranium gel was adding 10 times the amount of water, boiling twice, 1 h each; the best matrix prescriptions were carbomer 940 1.5%, glycerol 2%, propylene glycol 2% Triethanolamine 5%. Conclusion: The extraction process is simple and feasible, the preparation process is stable, the finished product is easy to coat and the texture is even and fine.