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已知干扰素对实验性肿瘤具有对抗作用,可能是通过抑制细胞分裂与增加免疫活性的途径,即激活天然杀伤细胞来实现。注射成纤维细胞干扰素于肌肉或皮下后,在血液循环中通常看不见,这可能是由于被组织结合了。因此,在临床研究需要全身效果时,须做静脉注射。Vallbracht等人报道的病例临床反应欠佳。在监测所注射的干扰素的药物动力学时,血液中未发现干扰素。但在血液循环中却发现了一种抗干扰素球蛋白。这显然是由于反复注射干扰素的缘故。而其他病人却没有出现这种情况。这意味着什么呢? 根据对细胞系的人类基因的分析,可以清楚地看出干扰素属于分子类。很明显,8种不同干扰素α(干扰素α或白细胞干扰素)就有各异的基因,而干扰素β(成纤维细胞干扰素)可能也是一种以上基因的产物。然而,各种干扰素的确好象是“不良”的抗原
It is known that interferon has an antagonistic effect on experimental tumors, probably by inhibiting the cell division and increasing the immune activity, that is, activating natural killer cells. Injecting Fibroblast Interferon Following muscle or subcutaneous injection, it is usually not visible in the blood circulation, probably due to tissue binding. Therefore, intravenous injection is required when clinical studies require systemic effects. The clinical response reported by Vallbracht et al. Is poor. In monitoring the pharmacokinetics of the injected interferon, no interferons were found in the blood. But in the blood circulation has found an anti-interferon globulin. This is obviously due to repeated injections of interferon. Other patients did not have this situation. What does this mean? Based on an analysis of the human genes in cell lines, it is clear that interferons belong to the class of molecules. Clearly, there are different genes for the eight different interferon alphas (interferon alpha or leukocyte interferon), and interferon beta (fibroblast interferon) may also be the product of more than one gene. However, various interferons do appear to be “bad” antigens