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A new monotetrahydrofuran Annonaceous acetogenin, gardnerin (1) was isolated from the roots of Goniothalamus gardneri Hook. f. et. Thoms. This compound possesses five hydroxyl groups, with two hydroxyl groups at C-8 and C-10 positions, The absolute stereochemistry at 8-OH and 10-OH positions was determined by converting 1 to its ketolactone isomer, 2,4-cisltrans gardnerin. Bioactivities of this new compound against human tumor cell lines are reported. Five known acetogenin compounds gigantetrocin A and B, annonacin,goniothalamicin, isoannonacin were also found.
A new monotetrahydrofuran Annonaceous acetogenin, gardnerin (1) was isolated from the roots of Goniothalamus gardneri Hook. F. Et. Thoms. This compound possesses five hydroxyl groups, with two hydroxyl groups at C-8 and C-10 positions, The absolute stereochemistry at 8-OH and 10-OH positions was determined by converting 1 to its ketolactone isomer, 2,4-cisltrans gardnerin. Bioactivities of this new compound against human tumor cell lines are reported. Five known acetogenin compounds gigantetrocin A and B, annonacin, goniothalamicin, isoannonacin were also found.