抗利尿激素(vasopressin,VP)主要在下丘脑的室旁核和视上核合成,经神经垂体分泌进入循环系统,分泌量取决于血浆渗透压和血容量。VP神经元向其他脑区都有投射,尤其是边缘系统,包括中隔及海马系统。已有文献报道VP及其代谢产物可以调节海马的theta节律,易化记忆过程。母婴分离模型已经被证实可以上调下丘脑的VP系统,而大脑内释放的VP可以引起很多行为学上的改变,比如主动或被动的逃避行为,社会认知以及学习和记忆行为。但是VP对空间认知能力的影响还不是很明确。在本研究中,笔 Vasopressin (vasopressin, VP) mainly in the hypothalamic paraventricular nucleus and supraoptic synthesis, the secretion of the nervous pituitary into the circulatory system, the secretion depends on the plasma osmolality and blood volume. VP neurons project to other brain regions, especially the limbic system, including the septum and hippocampus. It has been reported in the literature that VP and its metabolites regulate theta rhythm of the hippocampus to facilitate the process of memory. The maternal-fetal separation model has been shown to up-regulate the hypothalamic VP system, and the release of VP in the brain can cause many behavioral changes, such as active or passive avoidance behavior, social cognition, and learning and memory behaviors. However, the impact of VP on spatial cognitive ability is not yet clear. In this study, pen