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目的和方法：配制一种肝保护液，１００ｍＬ主要含有果糖７５ｇ、谷胱苷肽１５ｇ、别嘌呤醇２５ｇ、维生素Ｅ０３ｇ、地塞米松１０ｍｇ、川芎嗪０４ｇ、山莨菪碱１０ｍｇ和丹参２０ｍＬ。采用大鼠常温肝缺血６０ｍｉｎ－再灌注模型，治疗组４０只大鼠于缺血前１０ｍｉｎ和再灌注前１０ｍｉｎ，静注肝保护液１ｍＬ／ｋｇ，对照组４０只大鼠静注平衡液１ｍｌ／ｋｇ。结果：治疗组术后７ｄ存活率为６０％（１２／２０），而对照组为１５％（３／２０）；治疗组术后血清水平和再灌注后肝坏死范围明显低于对照组（Ｐ＜００５）。结论：肝保护液对大鼠肝常温缺血再灌注损伤具有明显的防治作用，这与减轻肝血窦阻力、增加肝血流，改善肝脏微循环障碍有关。
Objective and Methods: Preparation of a liver protection solution, 100mL mainly contains fructose 7 5g, glutathione 1 5g, allopurinol 2 5g, vitamin E 3g, dexamethasone 10mg, ligustrazine 0 4g, Anisodamine 10mg and Salvia 20mL. Forty rats in the treatment group were treated with intravenous injection of hepatic protective solution 1 mL / kg 10 min before ischemia and 10 min before reperfusion, / Kg. Results: The survival rate of the treatment group was 60% (12/20) at 7 days and 15% (3/20) in the control group. The postoperative serum levels of hepatic necrosis and the extent of hepatic necrosis after reperfusion in the treatment group were significantly lower than those in the control group <005). Conclusion: Liver protection solution has obvious preventive and therapeutic effects on rat liver ischemia-reperfusion injury at normal temperature, which is related to reducing resistance of hepatic sinusoids, increasing hepatic blood flow and improving hepatic microcirculation.