在美国美散酮用于维持治疗阿片样物质依赖的患者。阿片样依赖者易患情感性疾病,这种情况除美散酮治疗外,有时还需要抗抑郁药物治疗。去甲丙咪嗪治疗抑郁症的同时用美散酮,观察到给予相对低剂量的去甲丙咪嗪时患者有效,但出现副作用,去甲丙咪嗪血浓度比预期的高得多。为此,本文系统地研究了美散酮与去甲丙咪嗪的相互作用。 US-based medroxyphenone is used to maintain opioid dependence in patients. Opioid-dependent predisposition to emotional illness, in this case in addition to the United States and more ketone treatment, sometimes antidepressant medication is also needed. Synergism with mepronidone in the treatment of depression was observed in patients treated with relatively low doses of desipramine, but with side effects, the plasma concentration of desipramine was much higher than expected. For this reason, this article systematically studied the interaction of MEA and desipramine.