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探讨替硝唑 (TNZ)注射液防治妇产科疾患及手术患者厌氧菌感染的作用 ,并与甲硝唑 (MNZ)注射液进行比较。方法 :静脉滴注每 2 0 0ml含TNZ 80 0mg或每 2 0 0ml含MNZ 10 0 0mg ,疗程妇科 5d ,产科 3d。用药前后分别做厌氧菌分离培养 ,并比较两种注射液对 3株标准株和 10 7株临床分离厌氧菌的抗菌活性。结果 :TNZ组和MNZ组厌氧菌转阴或明显减少者分别为 91.0 %和 44.0 % ,有效率 94.0 %和 82 .0 %。提示TNZ对厌氧菌的抑制程度和疗效均明显优于MNZ(P <0 .0 1)。体外药敏试验结果亦证实 ,TNZ的药物敏感率 >MNZ ,前者的MIC和MBC为 0 .39～ 5 0 .0 0mg L ,后者为0 .78～ 10 0 .0 0mg L。结论 :TNZ防治女性生殖道厌氧菌感染明显优于MNZ。
To investigate the effect of tinidazole (TNZ) injection in prevention and treatment of anaerobic infections in obstetrics and gynecology patients and surgical patients, and to compare with metronidazole (MNZ) injection. Methods: Intravenous infusion every 200ml containing TNZ 80 0mg or every 200ml containing MNZ 10 0mg, treatment gynecology 5d, obstetric 3d. Anaerobic bacteria were isolated and cultured before and after treatment, and the antibacterial activity of the two injections against 3 standard strains and 107 clinically isolated anaerobes was compared. Results: The anaerobic bacteria in TNZ group and MNZ group were negative or significantly decreased by 91.0% and 44.0%, respectively, with the effective rates of 94.0% and 82.0%. Tip TNZ inhibitory effect of anaerobic bacteria and efficacy were significantly better than MNZ (P <0. In vitro susceptibility test results also confirmed that TNZ drug susceptibility> MNZ, the former MIC and MBC 0.39 ~ 50 0 0 mg L, the latter 0.78 ~ 10 0. Conclusion: TNZ is superior to MNZ in controlling female genital anaerobic infections.