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作者报告自1例抗-HBe阳性的慢性乙型肝炎男性患者得到一种有缺失的HBV。这种病毒不能产生大、中表面蛋白,因为在前S区有一长段缺失,而且有一终止密码子嵌入。在2年观察期间,这种变异病毒曾消失,随后又再出现。作者作了一系列血清检测,.调查与突变有关的前S抗原和相应的抗体产物,以期弄清导致这一变异病毒出现的机理及它对疾病经过的影响。患者42岁,日本人,男性。患慢性乙型肝炎,HBsAg和抗-HBe阳性,抗-HBs和HBeAg阴性,抗-C100和抗-HDV阴性,
The authors report that one missing HBV was obtained from one of the anti-HBe positive chronic hepatitis B male patients. The virus does not produce large, medium surface proteins because of a long stretch of pre-S and a stop codon. During 2 years of observation, this variant virus disappeared and then reappeared. The authors made a series of serological tests to investigate the mutation of the pre-S antigen and the corresponding antibody products in order to find out the mechanism that led to this variant virus and its impact on disease progression. Patient 42 years old, Japanese, male. Chronic hepatitis B, HBsAg and anti-HBe positive, anti-HBs and HBeAg negative, anti-C1OO and anti-HDV negative,