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目的 比较双相抑郁与首发抑郁症患者汉语成语N400成分的差异.方法 纳入双相抑郁患者(BPD组)41例,首发抑郁症患者(FED组)43例,以及健康对照(HC组)40例,应用17项汉密尔顿抑郁量表(HAMD-17)及汉语成语N400进行检测.结果 三组同音异形异义、形似异音异义、同义异音异形、异音异形异义的匹配和非匹配潜伏期比较差异均有统计学意义(P<0.05).进一步两两比较显示,与HC组相比较,FED组所有4种类型的匹配和非匹配潜伏期均延长(P<0.05),BPD组同音异形异义的匹配和非匹配潜伏期延长(P<0.05);与FED组比较,BPD组异音异形异义的匹配和非匹配潜伏期均缩短(P<0.05).三组同音异形异义、形似异音异义、同义异音异形、异音异形异义的匹配波幅比较差异均有统计学意义(P<0.05),三组同音异形异义的非匹配波幅比较差异有统计学意义(P<0.05).进一步两两比较发现,BPD组与FED组和HC组分别比较,在同音异形异义、形似异音异义、同义异音异形的匹配波幅均增高(P<0.05);BPD组与FED组比较,异音异形异义的匹配波幅和同音异形异义的非匹配波幅均增高(P<0.05).结论 双相抑郁和首发抑郁症患者均存在语言功能异常.“,”Objective To explore the status of Chinese idiom-N400 in patients with bipolar depressive disorder and first-episode depressive disorder.Methods A total of 41 patients with bipolar depressive disorder in BPD group,43 patients with first episode depressive disorder in FED group,40 healthy people in control group were selected and assessed with 17-items Hamilton Depression Scale(HAMD-17)and Chinese idiom-N400.Results There were significant differences for the congruent and incongruent latencies of all types of N 400 between three groups(P<0.05).The congruent and incongruent latencies of all types of N400 in FED group were significantly more than those in control group(P<0.05).The congruent and incongruent latencies of ending words with same pronunciation but different forms and meanings in BPD group were significantly more than those in control group(P<0.05).The congruent and incongruent latencies of ending words with different pronunciation,forms and meanings in BPD group were significantly less than those in FED group(P <0.05).There were significant differences for the congruent latencies of all types and the incongruent amplitudes ofending words with different forms,meanings of N400 between three groups (P<0.05).The congruent amplitudes of ending words with same pronunciation but different forms and meanings,with similar forms but different pronunciation and meanings,with same meanings but different pronunciation and forms of N 400 in BPD group and FED group were all significantly more than those in control group(P<0.05).The congruent amplitudes of ending words with different pronunciation,forms and meanings,the incongruent amplitudes of ending words with same pronunciation but different forms and meanings of N400 in BPD group were all significantly more than those in FED group(P<0.05).Conclusion There is abnormal for the function of language in the patients with bipolar depressive disorder and first -episode depressive disorder.