论文部分内容阅读
对２０只健康豚鼠进行正弦摆动下的眼震电图（ＥＮＧ）记录，并在平静状态和加速度不断变化的旋转过程中分别进行胃电图（ＥＧＧ）记录。然后对肌注庆大霉素（２５０ｍｇ·ｋｇ－１／日）３天的动物复查ＥＮＧ和ＥＧＧ，对正常饲养３天者复查ＥＧＧ，最后处死全部动物，用电镜进行内耳形态学观察。结果表明，在旋转加速度刺激下胃电振幅明显增加，与平静状态相比差异具有显著性；当前庭性眼震明显减弱，前庭终器部分受损时，加速度刺激不能诱发豚鼠的胃电变化。结论认为，加速度不断变化的旋转刺激可做为豚鼠运动病的诱发方式，胃电振幅的改变可做为豚鼠运动病模型的客观评判指标，且前庭终器对诱发运动病是必需的。
Twenty healthy guinea pigs underwent sinusographic electrognephurography (ENG) recording and electrogastrogram (EGG) recordings were performed during periods of steady state and constant acceleration of rotation. The animals were then injected with gentamycin (250 mg · kg-1 / day) for 3 days. The animals were examined for EGG and EGG for 3 days. EGG was then sacrificed and all the animals were sacrificed by electron microscopy. The results showed that the amplitude of gastric electrical activity increased obviously under the acceleration of rotational acceleration, and the difference was significant compared with that of the resting state. When the nocturnal nystagmus was significantly weakened and the partial damage of the vestibular finisher could not induce the changes of the electrogastrogram of guinea pigs. It is concluded that the rotational acceleration with changing acceleration can be used as the inducing mode of guinea pig motion sickness. The change of gastric electrical amplitude can be used as the objective judgmental index of guinea pig motion sickness model, and the vestibular finisher is necessary to induce motion sickness.