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目的探讨家庭氧疗(LTOT)联合吸入布地奈德福莫特罗对减少慢性阻塞性肺疾病(COPD)急性发作的治疗效果。方法选取2012年9月至2014年3月收治的COPD患者86例为研究对象,随机抽签分为观察组和对照组各43例,对照组实施家庭长期氧疗、督促按时服药、祛痰平喘、运动锻炼等常规疗法,观察组在常规治疗基础上给予布地奈德福莫特罗干粉吸入剂,测定治疗后6个月所有患者的肺功能,并应用圣乔治呼吸问卷(SGRQ)和运动耐量(6分钟步行实验,6MWD)评价总体健康状况,同时统计出院1年内急性发作率。结果 6个月后观察组的SGRQ评分显著低于对照组,且其6MWD(448.73±16.01)m显著高于对照组(301.56±2.84)m(P<0.05);观察组在实施联合治疗方案后,其肺功能较对照组显著改善,1年内急性发作率(9.3%)显著低于对照组(25.6%)(P<0.05)。结论单独使用家庭氧疗法能取得一定疗效,联合吸入布地奈德福莫特罗后可以进一步抑制病情恶化,改善临床症状,并提高患者生活质量,对COPD患者康复有重要意义。
Objective To investigate the therapeutic effect of domestic oxygen therapy (LTOT) combined with inhaled budesonide formoterol on acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Totally 86 COPD patients who were admitted to our hospital from September 2012 to March 2014 were enrolled in this study. All patients were randomly divided into observation group and control group, with 43 cases in each group. The control group was given long-term home oxygen therapy to urge patients to take medication on time and to expectorant and antiasthmatic , Exercise training and other routine therapies. The observation group was given budesonide formoterol dry powder inhalation on the basis of routine treatment. The lung function of all the patients at 6 months after the treatment was measured. The St George’s Respiratory Questionnaire (SGRQ) and exercise tolerance (6-minute walking test, 6MWD) to assess overall health status, and statistics of acute exacerbation within 1 year of discharge. Results After 6 months, the SGRQ score of the observation group was significantly lower than that of the control group, and the 6MWD (448.73 ± 16.01) m was significantly higher than that of the control group (301.56 ± 2.84) m (P <0.05). After the combination therapy (P <0.05). The acute lung injury rate in one year was significantly lower than that in control group (9.3% vs 25.6%, P <0.05). Conclusion Domestic oxygen therapy alone can achieve certain curative effect. Combination inhalation of budesonide formoterol can further inhibit the progression of the disease, improve the clinical symptoms and improve the quality of life of patients, which is of great significance to the rehabilitation of COPD patients.