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目的：比较缓释型硝苯地平与氨氯地平的动态降压作用。方法：１７例中、轻度原发性高血压病人（男性８例，女性９例，年龄４３±ｓ６ａ）８例予缓释型硝苯地平２０ｍｇ，ｐｏ，ｑｄ，９例予氨氯地平５～１０ｍｇ，ｐｏ，ｑｄ，×４ｗｋ。服药前、后做２４ｈ动态血压测定及踏车运动激发试验（ｎ＝１６）。结果：２药均有效地降低２４ｈ平均血压，但降压谷／峰（Ｔ／Ｐ）比值，收缩压（ＳＢＰ）Ｔ／Ｐ比值缓释硝苯地平组高于氨氯地平组，分别为８７％与７４％；舒张压（ＤＢＰ）Ｔ／Ｐ比值氨氯地平组高于缓释硝苯地平组，分别为８１％与６２％；运动激发下，服氨氯地平后ＤＢＰ仍能显著下降（Ｐ＜０．０１）及心率减慢（Ｐ＜０．０５）。结论：氨氯地平降２４ｈＤＢＰ的平稳性及对运动的耐受性均较缓释硝苯地平好。
Objective: To compare the dynamic antihypertensive effect of sustained-release nifedipine and amlodipine. Methods: Seventeen patients with mild essential hypertension (8 males and 9 females, age 43 ± s6a) were treated with sustained-release nifedipine 20 mg, po, qd and 9 with amlodipine 5 ~ 10mg, po, qd, × 4wk. 24h medication before and after ambulatory blood pressure and treadmill exercise challenge test (n = 16). Results: All the two drugs effectively reduced 24h mean blood pressure, but the ratio of T / P and SBP T / P was significantly lower in nifedipine group than in amlodipine group, respectively % And 74%, respectively. DBP T / P ratio in amlodipine group was significantly higher than that in sustained release nifedipine group (81% and 62%, respectively) P <0.01) and heart rate (P <0.05). CONCLUSION: The stability of amlodipine for 24hDBP and its tolerance to exercise are better than that of nifedipine.