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目的探讨局灶性原发性脑内淋巴瘤的诊治特点,提高诊疗水平。方法回顾性分析8例术后经病理组织学和免疫组化确诊为原发性脑内B细胞型淋巴瘤的临床资料。结果4例术后γ刀放疗加化疗平均生存55个月,3例普通放疗加化疗平均生存42个月,1例术后放弃治疗生存4.5个月。术后脊髓转移1例。结论原发性脑内淋巴瘤幕上多发,病史较短,临床表现无特异性,影像学有自身特点,确诊依赖于组织病理和免疫组化,术中特点利于早期诊断,术后放、化疗可延长生存期。
Objective To investigate the diagnosis and treatment of focal primary intracerebral lymphoma and to improve the diagnosis and treatment. Methods The clinical data of 8 patients diagnosed as primary intracerebral B-cell lymphoma by histopathology and immunohistochemistry were retrospectively analyzed. Results The average survival time of 4 cases treated with γ knife radiotherapy plus chemotherapy was 55 months. The average radiotherapy and chemotherapy of 3 cases survived for 42 months. One case gave up the treatment for 4.5 months after operation. Postoperative spinal cord metastasis in 1 case. Conclusions Primary intracerebral lymphoma is frequently found on the supratentorial surface, with a short history and non-specific clinical manifestations. Imaging has its own characteristics. The diagnosis depends on histopathology and immunohistochemistry. Intraoperative features are conducive to early diagnosis, postoperative radiotherapy and chemotherapy Can extend the survival period.