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目的系统评价中国人H型高血压与急性冠脉综合征的相关性。方法计算机检索PubMed、Web of Science、CNKI、CBM、VIP和WanFang Data数据库,全面搜集有关中国人H型高血压与急性冠脉综合征相关性的病例-对照研究,检索时限均为从建库至2015年5月。由两位研究者独立筛选文献、提取资料,并评价纳入研究的偏倚风险后,采用RevMan 5.2软件进行Meta分析。结果共纳入6个研究,共计992例研究对象,其中急性冠脉综合征患者(病例组)438例,对照组554例。Meta分析结果显示,病例组的H型高血压患者比例明显高于对照组,其差异有统计学意义[OR=3.32,95%CI(2.21,4.98),P<0.000 01]。结论现有证据表明,中国人H型高血压与急性冠脉综合征的发病具有关联性。受纳入研究数量和质量的限制,上述结论尚需开展更多高质量研究予以验证。
Objective To systematically evaluate the correlation between Hypertension and acute coronary syndrome in Chinese. Methods We searched PubMed, Web of Science, CNKI, CBM, VIP and WanFang Data databases for a comprehensive case-control study of the association between Hypertension and acute coronary syndrome in Chinese. May 2015. Two researchers independently screened the literature, extracted the data, and assessed the risk of being included in the study after the meta-analysis using RevMan 5.2 software. Results A total of 6 studies were included in the study, totaling 992 subjects, including 438 patients with acute coronary syndrome (case group) and 554 patients with control group. Meta-analysis showed that the proportion of patients with Hypertension in the case group was significantly higher than that of the control group (OR = 3.32, 95% CI 2.21, 4.98, P 0.0001). Conclusions The available evidence suggests that H-hypertension in Chinese is associated with the development of acute coronary syndrome. Subject to the limitations on the quantity and quality of the studies, the above conclusion still needs to be verified by more high-quality studies.