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目的:分析匹多莫德口服液对肺炎支原体肺炎(MPP)患儿综合免疫状态的改善作用。方法:将180例支原体肺炎患儿随机分为对照组和观察组各90例,对照组采用阿奇霉素10 mg/(kg·d)等常规基础治疗,观察组加用匹多莫德口服液每次10 m L,2次/天。采用免疫速率散射比浊法测定患儿血清免疫球蛋白和补体水平,流式细胞术检测患儿的T细胞亚群变化。结果:观察组患儿发热、咳嗽、肺部啰音等临床症状消失时间和白细胞计数、C反应蛋白水平恢复正常时间均显著短于对照组,观察组治疗总有效率为93.33%,显著高于对照组的81.11%(P<0.05)。治疗7 d、14 d后,观察组患儿Ig A、Ig G水平显著高于对照组,而Ig E和补体C3、C4水平则显著低于对照组;CD3+、CD4+水平和CD4+/CD8+显著高于对照组,CD8+水平则显著低于对照组(P<0.05)。结论:匹多莫德能有效改善MPP患儿的综合免疫状态,有利于患儿的康复。
Objective: To analyze the effect of Pidotimod on the comprehensive immune status in children with Mycoplasma pneumoniae pneumonia (MPP). Methods: 180 cases of children with mycoplasma pneumonia were randomly divided into control group and observation group of 90 cases, the control group with azithromycin 10 mg / (kg · d) and other conventional basic treatment, the observation group plus Pidotimod oral solution each time 10 m L, 2 times / day. Serum immunoglobulin and complement levels were measured by immunovoltmetric nephelometry. The changes of T lymphocyte subsets in children were detected by flow cytometry. Results: The disappearance of clinical symptoms, white blood cell count and C-reactive protein in observation group were significantly shorter than those in control group in fever, cough and pulmonary rales. The total effective rate in observation group was 93.33%, significantly higher than that in control group 81.11% of the control group (P <0.05). The levels of Ig A and Ig G in the observation group were significantly higher than those in the control group after 7 and 14 days of treatment, while the levels of Ig E and complement C3 and C4 in the observation group were significantly lower than those in the control group; CD3 +, CD4 + and CD4 + / CD8 + In the control group, the level of CD8 + was significantly lower than that of the control group (P <0.05). Conclusion: Pidotimod can effectively improve the comprehensive immune status of children with MPP and is beneficial to the rehabilitation of children.