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目的:结合既往临床病例及文献复习，总结促性腺激素释放激素激动剂（gonadotropin-releasing hormone agonist，GnRH-a）垂体降调节后多卵泡发育的诊疗特征。方法:报道1例于本院应用GnRH-a垂体降调节后多卵泡发育的患者情况，并结合中外文献报道的16例个案的病例特点进行回顾性分析。结果:应用GnRH-a后发生多卵泡发育的情况，目前无法预测亦无法避免。应用GnRH-a后的“flare-up”效应和卵泡刺激素受体基因的突变可能是发病原因。结论:GnRH-a垂体降调节后多卵泡发育可行取卵手术，建议新鲜周期全部胚胎冷冻，择期行冻融胚胎移植。“,”Objective:To summarize the diagnosis and treatment characteristics of multiple ovarian follicles growed after pituitary downregulation by gonadotropin-releasing hormone agonist (GnRH-a).Methods:This paper reported one patient with multiple ovarian follicles growed after pituitary downregulation using GnRH-a in our hospital, and the characteristics of 16 cases reported in Chinese and foreign literatures were retrospectively analyzed.Results:It is difficult to predict and avoid the development of multiple ovarian follicles after application of GnRH-a, and the “flare-up” effect after application of GnRH-a and the mutation of follicle-stimulating hormone (FSH) receptor gene may be the cause of the disease.Conclusion:The oocyte extraction operation is feasible for multiple ovarian follicles growed after pituitary downregulation. It is suggested to freeze the whole embryos in fresh cycle, and conducted embryo thawing transplantation at another time.