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B-7601为人工合成的新抗胆硷药物。它对离体蟾蜍心脏呈现抑制作用,能明显对抗乙酰胆硷作用,而与异丙肾上腺素有协同作用。B-7601能增强离体兔心冠脉流量。静注B-7601大鼠心脏呈现负性频率作用和负性传导作用。 B-7601能对抗大鼠静注氯化钡和乌头硷引起的心律失常,并其作用强于阿托品和东莨菪硷。B-7601尚能明显抑制小鼠吸入氯仿诱发的室性纤颇和氯仿一肾上腺素引起的家兔心律失常。 B-7601具有明显的表面麻醉作用,其作用强于普鲁卡因,约相当于的卡因。 小鼠静注B-7601的ED_(50)为0.76(0.74-0.78)mg/kg,LD_(50)为7.15(7.12-7.19)mg/kg,其治疗指数为9.35。
B-7601 is a synthetic new anticholinergic drug. It exerts inhibitory effect on the isolated heart of toad, can obviously antagonize the action of acetylcholine and has synergistic effect with isoproterenol. B-7601 can enhance isolated rabbit coronary flow. Intravenous injection of B-7601 rat heart showed negative frequency and negative conduction. B-7601 can antagonize the intravenous administration of barium chloride and aconitine induced arrhythmia in rats, and its role is stronger than atropine and scopolamine. B-7601 still can significantly inhibit mice inhaled chloroform-induced ventricular fibrillation and chloroform-adrenergic induced arrhythmia in rabbits. B-7601 has obvious surface anesthesia, its role is stronger than procaine, ca. In mice, the ED_ (50) of intravenous injection of B-7601 was 0.76 (0.74-0.78) mg / kg and the LD50 was 7.15 (7.12-7.19) mg / kg. The therapeutic index was 9.35.