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目的:观察山楂消脂胶囊对代谢综合征(MS)并颈动脉硬化(CAS)患者颈动脉内-中膜厚度(IMT)和斑块积分的影响。方法:将符合诊断标准的82例MS并CAS患者随机分为两组。对照组40例予改善生活方式并控制好相关危险因素,治疗组42例在对照组基础上加用山楂消脂胶囊,疗程为6个月。观察心脑血管事件的发生率,同时比较两组治疗前后颈动脉的IMT和斑块积分,并测定治疗前后Hs-CRP、Hcy、HOMA-IR各指标的变化。结果:治疗组急性心脑血管事件发生率较对照组有降低的趋势,但差异无统计学意义(P>0.05)。治疗组的颈动脉IMT和斑块积分低于对照组,差异有统计学意义(P<0.05),同时治疗组可明显降低Hs-CRP、Hcy、HOMA-IR,与对照组比较,差异有统计学意义(P<0.01)。结论:山楂消脂胶囊可能通过降低代谢综合征患者颈动脉斑块中的脂质含量,抗炎症反应,抗胰岛素抵抗,减轻颈动脉内中膜的厚度和斑块积分,从而稳定斑块,减少急性心脑血管事件的发生。
Objective: To observe the effect of hawthorn Xiaozhi capsule on carotid intima - media thickness (IMT) and plaque integral in patients with metabolic syndrome (MS) and carotid atherosclerosis (CAS). Methods: According to the diagnostic criteria of 82 cases of MS and CAS patients were randomly divided into two groups. Control group, 40 cases to improve the lifestyle and control of the relevant risk factors, the treatment group of 42 patients in the control group based on the use of hawthorn Xiaozhi capsules, treatment for 6 months. The incidence of cardiovascular and cerebrovascular events was observed. The carotid IMT and plaque score were compared before and after treatment. The changes of Hs-CRP, Hcy and HOMA-IR before and after treatment were also measured. Results: The incidence of acute cardiovascular and cerebrovascular events in the treatment group was lower than that in the control group, but the difference was not statistically significant (P> 0.05). The carotid IMT and plaque score in the treatment group were lower than those in the control group (P <0.05), and the Hs-CRP, Hcy and HOMA-IR in the treatment group were significantly lower than those in the control group Significance (P <0.01). Conclusion: Hawthorn Xiaozhi Capsule may reduce the lipid content, anti-inflammation, anti-insulin resistance and reduce the thickness of carotid artery intima-media and plaque score in patients with metabolic syndrome to stabilize plaque and reduce Occurrence of acute cardiovascular and cerebrovascular events.