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目的 评价慢性阻塞性肺疾病 (COPD)患者动脉二氧化碳分压 [Pa(CO2 ) ]与肺功能指标的多重相关关系及吸入支气管扩张剂后的影响。方法 91例COPD患者随机分为 3组 ,测定Pa(CO2 )、第 1秒时间肺活量(FEV1)、呼出气平均CO2 分压 [Pe(CO2 ) ]、功能残气量 (FRC)、潮气量 (VT) ;分别吸入不同的支气管扩张剂后 ,重复上述测定。结果 用药前Pa(CO2 )与Pe(CO2 )、潮气量 (VT)呈显著负相关。Pa(CO2 )与Pe(CO2 )、FEV1、功能残气量 (FRC)呈显著负相关。用药后 ,这种关系依然存在 ,且Pa(CO2 )在各组均出现下降 (P均 <0 0 5 ) ,在溴化异丙托品组 ,Pa(CO2 )的改变值与FRC的改变值显著呈正相关 ,在联合吸入组 ,Pa(CO2 )的改变值与VD/VT的改变值呈显著正相关。结论 COPD患者Pa(CO2 )与Pe(CO2 )、VT呈显著负相关 ,Pa(CO2 )与Pe(CO2 )、FEV1、FRC呈显著负相关。在吸入支气管扩张剂后 ,依然存在这种关系且使Pa(CO2 )下降 ,但不同的药物影响机制不同
Objective To evaluate the correlation between pulmonary arterial carbon dioxide partial pressure [Pa (CO2)] and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) and the effect of inhaled bronchodilator. Methods Ninety-one patients with COPD were randomly divided into three groups. Pa (CO2), FEV1, PeO2, functional residual capacity (FRC) and tidal volume ); After inhalation of different bronchodilators, the above measurement was repeated. Results Before treatment, Pa (CO2) was negatively correlated with Pe (CO2) and tidal volume (VT). Pa (CO2) and Pe (CO2), FEV1, functional residual capacity (FRC) showed a significant negative correlation. After treatment, this relationship still exists, and Pa (CO2) decreased in all groups (P <0.05). In the ipratropium bromide group, changes in Pa (CO2) and changes in FRC There was a significant positive correlation between the change of Pa (CO2) and the change of VD / VT in the combined inhalation group. Conclusions There was a significant negative correlation between Pa (CO2) and Pe (CO2) and VT in patients with COPD and negative correlation between Pa (CO2) and Pe (CO2), FEV1 and FRC. After bronchodilator inhalation, this relationship persists and decreases Pa (CO2), but different mechanisms of drug effects vary