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目的观察分析两家医院抗癫痫类药物应用的性别、年龄构成及不良反应,为临床用药提供依据。方法收集近5年来在两家医院治疗的癫痫患者的病例资料,其中花都区胡忠医院(A院)346例和花都区人民医院(B院)150例,对其抗癫痫药物的性别年龄构成情况及不良反应进行统计分析;探讨不良反应发生的相关因素及对策。结果两院性别比较,A院癫痫患者男性为254例(73.4%)、女性为92例(26.6%),B院癫痫患者[男性为99例(66.0%)、女性为51例(34.0%)],差异无统计学意义(P<0.05);两院年龄比较,A本院患者儿少组有295例(85.3%),成人组有51例(14.7%),与B院患者[儿少组38例(25.3%)、成人组112例(74.7%)]比较,差异有统计学意义(P<0.05);A院用药较陈旧,不良反应发生和多种因素有关。结论A院癫痫患者以男性占多数,且多数患者为少年、儿童;提倡应用新一代抗癫痫药物;为减少不良反应发生,在用药过程中,需要使用个体化给药方案。
Objective To observe and analyze the sex, age composition and adverse reactions of antiepileptic drugs in two hospitals and provide the basis for clinical medication. Methods The clinical data of epilepsy patients treated in two hospitals in the past five years were collected. Among them, 346 cases of Huzhong Hospital (Huayu District) and 150 cases of Huadu District People’s Hospital (Hospital B) Age composition and adverse reactions were analyzed statistically; to explore the relevant factors and countermeasures of adverse reactions. Results There were 254 males (73.4%) with epilepsy in hospital A, 92 (26.6%) females with epilepsy in hospital B [99 (66.0%) were males and 51 (34.0%) females) There was no significant difference between the two groups (P <0.05). Compared with the age of the two hospitals, 295 (85.3%) children in the A hospital and 51 (14.7% 38 cases (25.3%) in the adult group and 112 cases (74.7%) in the adult group]. There was a significant difference between the two groups (P <0.05). Conclusion A group of patients with epilepsy accounted for the majority of male patients, and most of the patients are young, children; to promote the application of a new generation of antiepileptic drugs; to reduce the adverse reactions occurred in the medication process, the need for the use of individualized dosing regimen.