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目的探究替吉奥胶囊治疗老年胃癌患者对患者血清中细胞凋亡抑制蛋白存活素(Survivin)、可溶性细胞间粘附因子-1(sICAM-1)及肿瘤标志物水平的影响。方法选择温州医科大学附属第三医院2013年5月—2015年11月治疗的62例老年胃癌患者,以随机数表法分组。对照组31例采用奥沙利铂+5-氟尿嘧啶(5-Fu)+亚叶酸钙方案治疗,观察组31例采用替吉奥+奥沙利铂方案治疗,均治疗3个疗程。统计对比2组临床疗效及毒副反应发生情况,检测对比2组治疗前后血管粘附因子(sVCAM-1)、sICAM-1、Survivin水平及肿瘤标志物变化情况。结果化疗前2组sICAM-1、sVCAM-1及Survivin水平比较差异无统计学意义(P>0.05);化疗后观察组sICAM-1、sVCAM-1及Survivin水平均低于对照组(P<0.05);化疗3个疗程后,观察组CEA、CA125及CA19-9水平低于对照组(P<0.05);2组治疗效果对比,差异无统计学意义(P>0.05);观察组胃肠道反应、白细胞减少总发生率低于对照组(P<0.05)。结论老年胃癌患者采用替吉奥胶囊联合奥沙利铂化疗效果显著,可有效降低sVCAM-1、sICAM-1、Survivin水平,降低肿瘤标志物水平,且安全性较高。
Objective To investigate the effects of treatment of geggio capsules on serum levels of survivin, soluble intercellular adhesion molecule-1 (sICAM-1) and tumor markers in elderly patients with gastric cancer. Methods Sixty-two elderly patients with gastric cancer who were treated in the Third Affiliated Hospital of Wenzhou Medical University from May 2013 to November 2015 were randomly divided into three groups. In the control group, 31 patients were treated with oxaliplatin + 5-Fu + leucovorin, and 31 patients in the observation group were treated with tioguanxide + oxaliplatin and were treated with 3 courses of treatment. The clinical curative effect and the occurrence of toxic and side reaction of the two groups were statistically compared. The changes of sVCAM-1, sICAM-1, Survivin and tumor markers in the two groups were compared before and after treatment. Results There was no significant difference in the levels of sICAM-1, sVCAM-1 and Survivin between the two groups before chemotherapy (P> 0.05), while the levels of sICAM-1, sVCAM-1 and Survivin in the observation group were lower than those in the control group ). After 3 courses of chemotherapy, the levels of CEA, CA125 and CA19-9 in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the therapeutic effect between the two groups (P> 0.05) Reaction, the total incidence of leukopenia than the control group (P <0.05). Conclusion The treatment effect of getiao capsule combined with oxaliplatin in elderly patients with gastric cancer is significant, which can effectively reduce the levels of sVCAM-1, sICAM-1 and Survivin, reduce the level of tumor markers and have higher safety.