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近年来 ,手术前后采用大剂量甲氨喋呤 (ＭＴＸ)配合甲酰四氢叶酸 (ＣＦ)解毒治疗骨肉瘤取得良好的疗效 ,化疗后不良反应以胃肠道反应 ,骨髓抑制 ,肝、肾、皮肤损害反应较为常见 ,而引起锥体外系反应的报道较少。 2 0 0 0年 10月至 11月我科发生 2例大剂量ＭＴＸ化疗引起锥体外
In recent years, the use of high-dose methotrexate (MTX) combined with leucovorin (CF) detoxification in the treatment of osteosarcoma has achieved good results before and after surgery. The adverse reactions after chemotherapy include gastrointestinal reactions, bone marrow suppression, liver, kidney, Skin damage reaction is more common, while the cause of extrapyramidal reactions reported less. 2 cases from October to November in our department occurred in 2 cases of high-dose MTX chemotherapy caused extrapyramidal