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骨与软组织恶性肿瘤一直是危害人类健康,特别是青少年致残、甚至致命的重要原因之一,近30年来随着化疗的开展及逐步完善,骨及软组织恶性肿瘤的治疗也取得了很大进展,特别近10多年以来,随着储存疗法在临床上的应用日趋完善,使化疗药物能反复通过动脉灌注方式给予,大大提高肿瘤局部的药物浓度,提高肿瘤坏死率,从而降低局部复发,提高患者保肢率,同时降低全身毒副反应。该疗法的使用为骨与软组织恶性肿瘤患者保留肢体及其功能带来了更大的希望。 1 储存疗法的历史及其应用于四肢骨与软组织恶性肿瘤的状况
Bone and soft tissue malignancies have been one of the most important causes of endangering human health, especially those of teenagers, and even fatalities. In the recent 30 years, with the progress of chemotherapy and gradual improvement, great progress has been made in the treatment of bone and soft tissue malignancies In recent 10 years, with the clinical application of storage therapy becoming more and more perfect, chemotherapeutic drugs can be repeatedly given through arterial infusion, which greatly improves local drug concentration in tumor and increases tumor necrosis rate, thus reducing local recurrence and improving patients’ Limb salvage rate, while reducing systemic toxicity. The use of this therapy offers greater hope for the retention of limbs and their function in patients with bone and soft tissue malignancies. 1 history of storage therapy and its application to limbs and soft tissue malignancies