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[目的]探讨奥沙利铂联合氟尿嘧啶同期调强适形放疗治疗局部晚期鼻咽癌的临床疗效.[方法]选自本院于2012年5月至2014年5月期间收治的局部晚期鼻咽癌患者82例,依据随机数表法分为观察组与对照组各41例.两组患者均采用三维调强适形放疗.对照组在调强放疗基础上同期采用顺铂化疗,观察组在调强放疗基础上同期采用奥沙利铂联合氟尿嘧啶化疗.两组均以21d为1个周期,连续2~4个周期.比较两组近期疗效,1年和3年局部复发情况、远处转移情况和生存情况及毒副反应发生情况.[结果]两组近期总有效率均为100.00%,差异无统计学意义(P>0.05);两组1年局部复发率比较无统计学差异(P>0.05).观察组3年局部复发率低于对照组(P0.05);观察组3年远处转移率低于对照组(P0.05);两组1年生存率比较无统计学差异(P>0.05);观察组3年生存率高于对照组(P0.05);1-year local recurrence rate showed no significant difference(P>0.05);3-years local recurrence rate of the observation group was lower than that of the control group(P0.05);3-year distant metastasis rate of the observation group was lower than that of the control group(P0.05);1-year survival rate of the two groups had no significant difference(P>0.05);3-year survival rate of the observation group was higher than that of the control group(P<0.05).[Conclusion] Oxaliplatin combined with 5-fluorouracil concurrent intensity-modulated radiotherapy is effective in the treatment of locally advanced nasopharyngeal carcinoma.It can reduce local recurrence and metastasis,and prolong the survival time,which is worthy of clinical application.