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本研究对71例妊娠12-36周的妇女（平均孕龄21．8周），自愿要求终止妊娠者，采用米索前列醇（misoprostol）800－1600μg分三次阴道给药（0小时、18小时、20小时或24小时）。观察给药至胎儿排出时间和用药后副作用。结果：米索前列醇单独阴道用药，不加任何辅助措施，62例（87.3％）在用药48小时内排出胎儿。若给予辅助治疗，催产素静滴（总量＜10单位）引产成功率为95．8％。平均引产时间22．8小时。平均出血约80ml，产后出血发生率1．4％。药物副作用主要表现为恶心呕吐、腹泻、发热，发生率分别为8．5％、25．4％、15．5％，停药后其症状自愈。提示：米索前列醇在中、晚期妊娠引产中，阴道给药配合辅助措施其引产成功率较高，副作用小，是一种非手术的、安全、高效、简便的药物引产方法。
This study of 71 women (121.8 weeks of mean gestational age) at 12-36 weeks of gestation, who voluntarily requested termination of pregnancy, was treated with misoprostol (800-1600 μg) three times vaginally (0 hour, 18 hours). , 20 hours or 24 hours). Observe the time of administration to the fetus and the side effects after medication. RESULTS: Misoprostol was administered vaginally alone without any auxiliary measures. 62 (87.3%) patients were discharged within 48 hours of treatment. If adjuvant therapy is given, the success rate of oxytocin instillation (<10 units total) is 95.8%. The average induction time was 22.8 hours. The average bleeding was about 80 ml, and the incidence of postpartum hemorrhage was 1.4%. The main side effects of drugs were nausea and vomiting, diarrhea, and fever. The incidence rates were 8.5%, 25.4%, and 15.5%, respectively. The symptoms were self-recovery after drug withdrawal. It is suggested that misoprostol is a non-surgical, safe, highly effective and simple drug induction method in the induction of labor in middle and late pregnancy.