Heat exchanger network optimization has an important role in high-efficiency energy utilization and energy conservation. The thermal resistance of a heat exchanger network is defined based on its entransy dissipation. In two-stream heat exchanger networks, only heat exchanges between hot and cold fluids are considered. Thermal resistance analysis indicates that the maximum heat transfer rate between two fluids corresponds to the minimum entransy-dissipation-based thermal resistance; i.e. the minimum thermal resistance principle can be exploited in optimizing heat exchanger networks. Heat exchanger network optimization has an important role in high-efficiency energy utilization and energy conservation. The thermal resistance of a heat exchanger network is defined based on its entransy dissipation. In two-stream heat exchanger networks, only heat exchanges between hot and cold fluids are considered. that the maximum heat transfer rate between two fluids corresponds to the minimum entransy-dissipation-based thermal resistance; ie the minimum thermal resistance principle can exploit in optimizing heat exchanger networks.