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目的:研究血清中血管内皮生长因子(VEGF)和组织因子(TF)的表达及其与急性白血病发生和发展的关系。方法:收集70例急性白血病患者(AL),其中初发未治者31例,完全缓解者14例,未缓解者7例,复发患者18例,另外选择20名健康体检者作为对照组,应用酶联免疫吸附试验(ELISA)法测定各组血清中VEGF及TF的含量,并进行统计学分析。结果:AL初发未治组、未缓解组、复发组患者血清VEGF和TF的含量均明显高于正常对照组和缓解组(P<0.01);而缓解组患者血清VEGF和TF的含量与正常对照组比较其差异无统计学意义(P>0.05);TF含量与VEGF含量在AL中呈显著正相关(r=0.675,P<0.01)。结论:VEGF和TF与AL的发生、发展密切相关,动态检测急性白血病患者的血清VEGF及TF水平对观察病情、预测复发、指导治疗均有十分重要的临床价值。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and tissue factor (TF) in serum and its relationship with the occurrence and development of acute leukemia. Methods: Seventy patients with acute leukemia (AL) were collected. Among them, 31 cases were newly diagnosed and untreated, 14 cases were complete remission, 7 cases were unresected, 18 cases were relapsed, and 20 healthy subjects were selected as control group. Serum levels of VEGF and TF in each group were determined by enzyme linked immunosorbent assay (ELISA), and statistical analysis was performed. Results: The levels of serum VEGF and TF in AL group were significantly higher than those in normal control group and remission group (P <0.01), while those in remission group were significantly higher than those in normal group There was no significant difference between the control group and the control group (P> 0.05). There was a significant positive correlation between the content of TF and the content of VEGF in AL (r = 0.675, P <0.01). Conclusion: VEGF and TF are closely related to the occurrence and development of AL. The dynamic detection of serum VEGF and TF levels in patients with acute leukemia has important clinical value in the observation of the disease, the prediction of relapse and the guidance and treatment.