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目的 探讨肠源性内毒素移位后在腹膜炎大鼠各脏器中分布。方法 以12 5I-LPS对大鼠灌胃后 ,检测各脏器单位组织重量中内毒素含量。结果 腹膜炎组各主要脏器单位重量中的内毒素含量增加 (P <0 0 5 ) ,由高至低为肾、肺、肝、胰、肠系膜淋巴结、心脏 (P <0 0 5 )。先锋Ⅵ号及多粘菌素B可降低腹膜炎大鼠脏器中内毒素含量。结论 急性感染性腹膜炎可致肠源性内毒素移位增加。腹膜炎时易发生肾衰、呼衰与其单位组织中内毒素含量有关。先锋Ⅵ号、多粘菌素B对肠源性内毒素移位有一定的抑制作用。
Objective To investigate the distribution of intestinal endotoxin in various organs of peritonitis rats after transposition. Methods After intragastric administration of 125 I-LPS to rats, the content of endotoxin in each organ tissue was measured. Results In peritonitis group, the content of endotoxin increased significantly (P <0.05) in all the major organs, ranging from high to low as kidney, lung, liver, pancreas and mesenteric lymph nodes and heart (P <0.05). Vanguard VI and polymyxin B can reduce endotoxin in rats with endotoxin content. Conclusions Acute infective peritonitis may result in increased translocation of intestinal endotoxin. Peritonitis prone to renal failure, respiratory failure and its unit of endotoxin content in the organization. Vanguard VI, polymyxin B on intestinal endotoxin translocation has a certain inhibitory effect.