胃溃疡是由于胃粘膜受到攻击因子(如胃酸、胃蛋白酶等)损伤或胃粘膜保护胃壁的功能减弱而产生。硫糖铝、雷尼替丁是临床治疗胃溃疡疗效较好的两种药物。硫糖铝口服不吸收,在水中释放氢氧化铝和硫酸多糖,起保护胃粘膜作用。霄尼替丁能抑制胃酸分泌,降低胃蛋白酶活性而起到保护作用。所以,我们选用硫糖铝和雷尼替丁观察其对四种大鼠胃溃疡模型(水浸应激型、乙酸灼烧型、乙醇致胃粘膜损伤型、幽门结扎型)作用及其特点。 Gastric ulcer is due to the gastric mucosa by attack factors (such as gastric acid, pepsin, etc.) damage or gastric mucosa to reduce the function of the stomach wall produced. Sucralfate, ranitidine is the clinical treatment of gastric ulcer two drugs better. Sucralfate oral does not absorb, release aluminum hydroxide and sulfuric acid polysaccharides in water, play a role in protecting the gastric mucosa. Sunditin can inhibit gastric acid secretion, reduce pepsin activity and play a protective role. Therefore, we used sucralfate and ranitidine to observe its effects on four rat models of gastric ulcer (flooding stress, acetic acid burning, alcohol induced gastric mucosal injury, pyloric ligation) and its characteristics.