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目的：探讨增殖性肾小球肾炎（ Ｐ Ｇ Ｎ）肾小球内单个核细胞（ Ｍ Ｎ Ｃ）白细胞介素 ２ 受体（ Ｉ Ｌ２ Ｒ）表达与细胞外基质积聚的关系。方法：用免疫组织化学方法检测人 Ｐ Ｇ Ｎ 肾小球内 Ｔ 细胞浸润和 Ｍ Ｎ Ｃ Ｉ Ｌ２ Ｒ的表达，同时用 Ｐ Ａ Ｓ染色方法结合计算机图象分析系统检测系膜区基质增生。结果： Ｐ Ｇ Ｎ 肾小球内 Ｔ细胞浸润及 Ｉ Ｌ２ Ｒ＋ Ｍ Ｎ Ｃ明显增多（ Ｐ ＜ ０．０１），正常肾组织内无 Ｉ Ｌ２ Ｒ＋ Ｍ Ｎ Ｃ； Ｐ Ｇ Ｎ 系膜区基质增生明显增加（ Ｐ ＜ ０．０１），且其与肾小球内 Ｉ Ｌ２ Ｒ＋ Ｍ Ｎ Ｃ数目呈显著正相关。结论： Ｐ Ｇ Ｎ 肾小球内 Ｉ Ｌ２ Ｒ 阳性表达与系膜区基质积聚密切相关，提示局部免疫活化是 Ｐ Ｇ Ｎ 的发生发展的重要参与因素。
Objective: To investigate the relationship between interleukin 2 receptor (IL-2R) expression and extracellular matrix accumulation in proliferating glomerulonephritis (P G N) glomerular. Methods: Immunohistochemistry was used to detect the infiltration of T cells and the expression of M N C I L2 R in human glomerular mesangial cells. Meanwhile, P A S staining combined with computer image analysis system was used to detect the proliferation of mesangial matrix . Results: The infiltration of T cells in glomeruli and IL-2 R + M N C in P G N group were significantly increased (P <0.01), but there was no I L2 R + M N C in normal renal tissues. Regional matrix proliferation was significantly increased (P <0.01), and its glomerular I L 2 R + M N C number was significantly positively correlated. CONCLUSION: The positive expression of IL-2R in glomeruli of P G N is closely related to the matrix accumulation in mesangium, suggesting that local immune activation plays an important role in the occurrence and development of P G N.