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顺铂(顺氯氨铂Cisplatin, Platinol)是最近上市的一种临床有效的抗肿瘤药物,是一种水溶性铂的配位络合物,经验式为PtCl_2H_6N_2,有两个氯原子和两个氨部分以顺式包围着中心铂原子。 1965年Rosenberg及其同事在研究电场对于大肠杆菌细胞膜的效应时,无意中发现了铂的抗肿瘤活性。他们观察到:大肠杆菌
Cisplatin (Platinol) is a clinically effective anticancer drug marketed recently. It is a water-soluble coordination complex of platinum with an empirical formula of PtCl_2H_6N_2 with two chlorine atoms and two The ammonia moiety surrounds the central platinum atom in cis. Rosenberg and his colleagues in 1965 in the study of the electric field on the cell membrane of E. coli, the unintentional discovery of the anti-tumor activity of platinum. They observed: E. coli